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1.ClemmonsDR, MosesAC, MckayMJ , et al. The combination of insulin-like growth factor 1 and insulin-like growth factor binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity. J Clin Endocrinol Metab 　2000; 85: 1518 2.MathonnetM , Comte I, L alloue F, et al. insulin-like growth factor 1 induce survival axotomixeed olfactory neurons in the chick. NeurosciLet t　2001; 308 (2) :667

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1.Bulter AA , M inireview LD, Tissue-specific versus generalized generalized gene tergeting of the Igf1 and Igf1-r genes and their roles in insulin-like growth factor physiology. Endocrinology　2001; 142 (5) : 1686 2.N ixon AJ , Brower-Toland BD, SandellLJ. Primary nucleotide structure of predominant and alternate splice forms of equine insulin-like growth factor 1 and thei rgene expression pat terns in tissue. Am J V et Res　1999;60: 1234

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ChenZ; Herman AE; Matos M; Mathis D; Benoist C. 2005. Where CD4+CD25+T reg cells impinge on autoimmune diabetes. J Exp Med 202(10): 1387-97.