痴呆症；帕金森病相关模型

1 Michetti F，Cazzlo D. S100B protein in biological fluids：a tool for perinatal medicine. Clin Chem. 2002；48（12）：2097 2 Hauschild A，Engel G，Brenner W，et al . S100B protein detection in serum is a significant prognostic factor in metastatic melanoma. Oncology. 1999；56（4）：338 3 Rustandi RR， Baldisseri DM， Weber DJ. Structure of the negative regulatory domain of p53 bound to S100B（betabeta）. Nat Struct Bio1. 2000；7（7）：570 4 Nagdyman N，Komen W，Ko HK，et al . Early biochemical indicators of hypoxic -ischemic encephalopathy after birth as-phyxia［J］. Pediatr Res. 2001 Apr；49（4）：502. 5 Gazzolo D， Vinesi P， Bartocci M， et al . Elevated S100 blood level as an early indicator of intraventricular hemorrhage in preterm infants. J Neurol Sci. 1999 Nov 15；170（1）：32

神经系统疾病模型

1 Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids[J]?? J Endocrinol, 2003,178:5-12. 2 Arooq A, Zhou MM. Structure and regulation of MAPK phosphatases[J]. Cell Signal.2004,16:769-79. 3 Hunter JJ, Tanaka N, Rockman HA, et al. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy in transgenic mice. J Boil Chem.1995, 270: 23173-23178. 4 Xu Q, Konta T, Nakayama K, et al. Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway. Free Radic Biol Med.,2004,36:985-93. 5 Kim GS,Kim WK, Han BH，et al. MKP-1 contributes to oxidative stress-induced apoptosis via inactivation of ERK1/2 in SH-SY5Y cells. Biochem Biophys Res Commun, 2005,338:1732-8. 6 Choi BH, Hur EM, Lee JH,et al. Protein kinase C delta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death[J].J Cell Sci,2006,119:1329-40. 7 Mizuno R, Oya M, Shiomi T, et al. Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. J Urol.2004, 172:723-7. 8 Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids[J]?? J Endocrinol, 2003,178:5-12. 9 Julie Wu and Anton M. Bennett. Essential Role for Mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP Kinase and cell survival signaling[J]. J Biol Chem.2005,280: 16461-16466.

神经系统疾病模型

1 Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids[J]?? J Endocrinol, 2003,178:5-12. 2 Arooq A, Zhou MM. Structure and regulation of MAPK phosphatases[J]. Cell Signal.2004,16:769-79. 3 Hunter JJ, Tanaka N, Rockman HA, et al. Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy in transgenic mice. J Boil Chem.1995, 270: 23173-23178. 4 Xu Q, Konta T, Nakayama K, et al. Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway. Free Radic Biol Med.,2004,36:985-93. 5 Kim GS,Kim WK, Han BH，et al. MKP-1 contributes to oxidative stress-induced apoptosis via inactivation of ERK1/2 in SH-SY5Y cells. Biochem Biophys Res Commun, 2005,338:1732-8. 6 Choi BH, Hur EM, Lee JH,et al. Protein kinase C delta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death[J].J Cell Sci,2006,119:1329-40. 7 Mizuno R, Oya M, Shiomi T, et al. Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. J Urol.2004, 172:723-7. 8 Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids[J]?? J Endocrinol, 2003,178:5-12. 9 Julie Wu and Anton M. Bennett. Essential Role for Mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP Kinase and cell survival signaling[J]. J Biol Chem.2005,280: 16461-16466.

癌症

1 Nagase T, Seki N, Ishikawa K,et al.The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.DNA Res. 1996,3(1):17-24. 2 Lim J, Hao T, Shaw C,et al. Protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration 2006,Cell 125 (4), 801-814. 3 Matsuda A, Suzuki Y, Honda G.et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways 2003, Oncogene 22 (21), 3307-3318. 4 袁劲松. 肺癌相关新基因的克隆与筛选及新的候选原癌基因KIAA0174的功能研究.2006,5月1日，中国协和医科大学博士学位论文 肿瘤学 指导教师：程书钧，高燕宁.

神经系统疾病相关模型

3.1 Oppenheim RW, Wiese S, Prevette D, et al. Cardiotrophin-1, a muscle-derived cytokine, is required for the survival of subpopulation of developing motoneurons. J Neurosci, 2001, 21(4): 1283-1291. 4.2 Pennica D, King KL, Shaw KJ, et al. Expression cloning of cardiotrophin-1, a cytokine that induces cardiac myocyte hypertrophy. Proc Narl Acad Sci USA, 1995, 92: 1142-1146. 5.3 Kunisada K, Negoro S, Tone E, et al. Signal transducer and activator of transcription 3 in the heart transducers not only a hypertrophy signal but a protective signal against doxombicinioduced cardiomyopathy. Proc Natl Acad Sci USA, 2000, 97(1): 315-319.

脂代谢相关，痴呆症相关

1 Naveed Sattar, MD Allan Gaw MD, Olga Scherbakova, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the west of Scotland coronary prevention study. Circulation. 2003, 108: 414-419. 2 沈丽华，柯开富，李作汉，等.载脂蛋白E基因多态性与脑梗死的相关性分析. 中风与神经疾病杂志. 2003，20（10）：445-447. 3 Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E denotype in the diagnosis of Alzheimer’s disease . N Engl J Med. 1998, 338(8): 506-511. 4 Refolo LM, Fillit HM. Apolipoprotein E4 as a target for developing new therapeutics for alzheimer’s disease. J Mol Neurosci. 2004, 23(3):151-155.

脂代谢相关，痴呆症相关

1 Naveed Sattar, MD Allan Gaw MD, Olga Scherbakova, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the west of Scotland coronary prevention study. Circulation. 2003, 108: 414-419. 2 沈丽华，柯开富，李作汉，等.载脂蛋白E基因多态性与脑梗死的相关性分析. 中风与神经疾病杂志. 2003，20（10）：445-447. 3 Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E denotype in the diagnosis of Alzheimer’s disease . N Engl J Med. 1998, 338(8): 506-511. 4 Refolo LM, Fillit HM. Apolipoprotein E4 as a target for developing new therapeutics for alzheimer’s disease. J Mol Neurosci. 2004, 23(3):151-155.

脂代谢相关，痴呆症相关

1 Naveed Sattar, MD Allan Gaw MD, Olga Scherbakova, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the west of Scotland coronary prevention study. Circulation. 2003, 108: 414-419. 2 沈丽华，柯开富，李作汉，等.载脂蛋白E基因多态性与脑梗死的相关性分析. 中风与神经疾病杂志. 2003，20（10）：445-447. 3 Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E denotype in the diagnosis of Alzheimer’s disease . N Engl J Med. 1998, 338(8): 506-511. 4 Refolo LM, Fillit HM. Apolipoprotein E4 as a target for developing new therapeutics for alzheimer’s disease. J Mol Neurosci. 2004, 23(3):151-155.

痴呆症

FRI-ZZ-LE9 启动子，构建Frizzled-9 - B2M

免疫系统疾病；神经系统疾病

基因打靶

1. Boyle, J. M.; Hey, Y.; Myers, K.; Stern, P. L.; Grzeschik, F.-H.; Ikehara, Y.; Misumi, Y.; Fox, M. : Regional localization of a trophoblast antigen-related sequence and 16 other sequences to human chromosome 6q using somatic cell hybrids. Genomics 12: 693-698, 1992. 2. Cain, D. P.; Grant, S. G. N.; Saucier, D.; Hargreaves, E. L.; Kandel, E. R. : Fyn tyrosine kinase is required for normal amygdala kindling. Epilepsy Res. 22: 107-114, 1995. 3. Chan, B.; Lanyi, A.; Song, H. K.; Griesbach, J.; Simarro-Grande, M.; Poy, F.; Howie, D.; Sumegi, J.; Terhorst, C.; Eck, M. J. : SAP couples Fyn to SLAM immune receptors. Nature Cell Biol. 5: 155-160, 2003. 4. Grant, S. G. N.; O'Dell, T. J.; Karl, K. A.; Stein, P. L.; Soriano, P.; Kandel, E. R. : Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258: 1903-1910, 1992.

神经系统疾病相关

胚胎干细胞打靶

1 Berghuis P, Dobszay MB, Wang X., et al.Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 2 Bibel M, Barde YA.Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14: 2919-2937, 2000. 3 Bothwell M. p75(NTR): a receptor after all. Science 272: 506-507, 1996. 4 Carter BD,Lewin GR.Neurotrophins live or let die: does p75(NTR) decide?? Neuron 18: 187-190, 1997.

痴呆症；帕金森病

基因打靶

1 杜静，秦川．胆囊收缩素作用的研究进展．中国比较医学杂志．2007，17（4）： 67-75． 2 Liddle RA. Cholecystokinin: its role in health and disease Curr Opin Endocrinol. Diabetes, 2003, 10(1):50-54. 3 Blevins JE, Stanley BG, Reidelberger RD. Brain regions where cholecystokinin suppresses feeding in rats. Brain Res, 2000, 860:1-10. 4 Appleyard SM, Bailey TW,Doyle MW,et al. Proopiomelanocortin Neurons in Nucleus Tractus Solitarius Are Activated by Visceral Afferents: Regulation by Cholecystokinin and Opioids. Neuroscience, 2005, 25(14):3578-3585.