重组酶工具小鼠

转基因

神经相关工具小鼠

1. Bayer K-U, De Koninck P, Leonard AS, et al. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411: 801-805, 2001. 2. Chen C, Rainnie DG, Greene RW, et al. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II. Science 266: 291-294, 1994. 3. Cho YH, Giese KP, Tanila H,et al. Abnormal hippocampal spatial representations in alpha-CaMKII(T286A) and CREB(alpha-delta-) mice. Science 279: 867-869, 1998. 4. Elgersma Y, Fedorov NB, Ikonen S, et al.Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron 36: 493-505, 2002. 5. Frankland PW, Bontempi B, Talton LE, et al.The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 304: 881-883, 2004. 6. Frankland PW, O'Brien C, Ohno M, et al. Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory. Nature 411: 309-313, 2001. 7. Karcher RL, Roland JT, Zappacosta F,et al. Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. Science 293: 1317-1320, 2001. 8. Li G, Laabich A, Liu LO,et al. Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain: sequence analyses of human brain calcium/calmodulin-dependent protein kinase II. Molec. Biol. Reports 28: 35-41, 2000. 9. Lu CS, Hodge JJL, Mehren J, et al.Regulation of the Ca(2+)/CaM-responsive pool of CaMKII by scaffold-dependent autophosphorylation. Neuron 40: 1185-1197, 2003. 10. Matsumoto Y, Maller JL, Calcium, calmodulin and CaMKII requirement for initiation of centrosome duplication in Xenopus egg extracts. Science 295: 499-502, 2002. 11. Thiagarajan TC, Piedras-Renteria ES, Tsien RW.Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.

重组酶工具小鼠

转基因

绿色荧光工具小鼠

基因敲入

重组酶工具小鼠

转基因小鼠

荧光小鼠

利用Thy-1启动子建立的黄色荧光蛋白小鼠

1. Abeysinghe HR, Cao Q, Xu J. THY1 expression is associated with tumor suppression of human ovarian cancer. Cancer Genet. Cytogenet. 143: 125-132, 2003. 2. Cao Q,Abeysinghe HR, Chow O,et al. Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11. Cancer Genet. Cytogenet. 129: 131-137, 2001. 3. Gatti RA, Lathrop GM, Salser W,et al. Location of Thy-1 with respect to a primary linkage map of chromosome 11q. (Abstract) Cytogenet. Cell Genet. 46: 618 only, 1987. 4. Gatti RA, Shaked R, Wei S,et al. DNA polymorphism in the human Thy-1 gene. Hum. Immun. 22: 145-150, 1988. 5. Greenspan RJ, O'Brien MC, Genetic evidence for the role of Thy-1 in neurite outgrowth in the mouse. J. Neurogenet. 5: 25-36, 1989.

发育疾病相关模型小鼠

干细胞打靶

1 Hong JH, Hwang ES, McManus, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309: 1074-1078, 2005. 2 Kanai F, Marignani PA, Sarbassova D, et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 19: 6778-6791, 2000. 3 Murakami M, Nakagawa M, Olson EN, et al.A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Nat. Acad. Sci. 102: 18034-18039, 2005.

肿瘤疾病相关模型小鼠

干细胞打靶

1. Brenner, O.; Levanon, D.; Negreanu, V.，et al., Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc. Nat. Acad. Sci. 101: 16016-16021, 2004. 2. Fainaru, O.; Shseyov, D.; Hantisteanu, S.; Groner, Y. : Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Nat. Acad. Sci. 102: 10598-10603, 2005. 3．Fainaru, O.; Woolf, E.; Lotem, J.，et al., Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J. 23: 969-979, 2004. 4. Fukamachi, H.; Ito, K. : Growth regulation of gastric epithelial cells by Runx3. Oncogene 23: 4330-4335, 2004. 5. Inoue, K,; Ozaki, S.; Shiga, T., et al., Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons. Nature Neurosci. 5: 946-954, 2002.

代谢性疾病相关模型小鼠

干细胞打靶

1 Chao Y, Xing Y, Chen Y, et al. Structure and mechanism of the phosphotyrosyl phosphatase activator. Molec. Cell 23: 535-546, 2006. 2 McCright B, Rivers AM, Audlin S, et al. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J. Biol. Chem. 271: 22081-22089, 1996. 3 Van Hoof C, Aly MS, Garcia A, et al. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. Genomics 28: 261-272, 1995.

肿瘤疾病相关模型小鼠

干细胞打靶

肿瘤疾病相关模型小鼠

干细胞打靶

1 Al-Awqati Q, Preisig PA. Size does matter: will knockout of p21(WAF1/CIP1) save the kidney by limiting compensatory renal growth? (Commentary) Proc. Nat. Acad. Sci. 96: 10551-10553, 1999. 2 Amack JD, Mahadevan MS. The myotonic dystrophy expanded CUG repeat tract is necessary but not sufficient to disrupt C2C12 myoblast differentiation. Hum. Molec. Genet. 10: 1879-1887, 2001. 3 Asada M, Ohmi K, Delia D, et al. Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation. Molec. Cell. Biol. 24: 8236-8243, 2004.

神经相关cre工具小鼠

转基因