肿瘤疾病相关模型小鼠

1. Mercatelli N, Coppola V, Bonci D, et al. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS One. 2008;3(12):e4029. 2. Mayoral RJ, Pipkin ME, Pachkov M, et al. MicroRNA-221-222 regulate the cell cycle in mast cells. J Immunol. 2009 ;182(1):433-445. 3. Miller TE, Ghoshal K, Ramaswamy B, et al. MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem.2008; 283(44): 29897--29903. 4. Galardi S, Mercatelli N, Giorda E, et al. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem. 2007; 282(32):23716-24.

神经系统疾病模型小鼠

1．Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S.A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex.Hum Mol Genet. 2008 Oct 1;17(19):3030-42. Epub 2008 2．Eva van Rooij,* Lillian B. Sutherland,* Ning Liu,* Andrew H. Williams,* John McAnally,* Robert D. Gerard,† James A. Richardson,*‡ and Eric N. Olson§.A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A. 2006 November 28; 103(48) 3．Van Rooij, E., Sutherland, L.B., Liu, N., Williams, A.H., Mcanally, J., Gerard, R.D., Richardson, J.A., And Olson, E.N. A signature pattern of stress-responsive micro-RNAs that can evoke cardiac hypertrophy and heart failure [J]. Proc. Natl. Acad. Sci. U.S.A. 2006.103, 18255–18260.

免疫相关

1 Liu G, Min H, Yue S, et al. Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. PLoS One. 2008;3(10):e3592. 2. Li QJ, Chau J, Ebert PJ, et al. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell. 2007;129(1):147-61. 3. Chen CZ, Li L, Lodish HF, et al. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004; 303(5654):83-6.

肿瘤疾病相关模型小鼠

1． Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG, Tan TM. Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma. Cancer Sci. 2009 Apr 15. [Epub ahead of print] 2．Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ. The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim.Gastroenterology. 2009 May;136(5):1689-700. 3．Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis. 2009 Mar;33(3):422-8. Epub 2008 Dec 9. 4.Petrocca F, Vecchione A, Croce CM. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 2008 Oct 15;68(20):8191-4. Review. 5．Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell. 2008 Mar;13(3):272-86. 6． Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, Linsley PS, Cleary MA. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol. 2008 Apr;28(7):2167-74. Epub 2008 Jan 22.

肿瘤疾病相关模型小鼠

1 Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells [J]. Oncogene, 2007, 26(34):5017-5022. 2. Sun F, Fu H, Liu Q, Tie Y, Zhu J, Xing R, Sun Z, Zheng X. Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest [J]. FEBS Lett, 2008, 582(10):1564-1568. 3. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells[J]. Proc Natl Acad Sci USA, 2007, 104(39): 15472-15477. 4. Yamakuchi M, Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis[J]. Proc Natl Acad Sci USA, 2008, 105(36): 13421-134266.

肿瘤疾病相关模型小鼠

心肌病

Chicken β-actin驱动的系统表达HB-EGF基因的转基因小鼠

Higashiyama S, Abraham JA., Miller J, et al. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science, 1991, 251: 936-939.

骨代谢相关

吕丹，陈炜，王书美等. Dkk3系统性表达转基因小鼠的建立.《中国比较医学杂志》2009年 第9期. 16-19页　

发育相关模型小鼠

靶基因信息: TERT, telomerase reverse transcriptase, human

免疫相关疾病

药物代谢相关模型

贫血小鼠

自发突变

1 Arguello F; Furlanetto RW; Baggs RB; Graves BT; Harwell SE; Cohen HJ; Frantz CN. 1992. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv). Cancer Res 52(8):2304-9PubMed: 1559233MGI: J:468 2 Cheers C; McKenzie IF. 1978. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun 19(3):755-62PubMed: 305895MGI: J:5965 3 Murphy ED. 1972. Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48(5):1283-95PubMed: 4337905MGI: J:5274