| 标识符 | CSTR:16397.09.0G01000327 |
|---|---|
| 资源中文名称 | Tcrb和Tcrd双敲除小鼠 |
| 资源英文名称 | B6.129P2-Tcrbtm1Tcrdtm1 |
| 疾病概述 | 免疫系统相关疾病 |
| 实验动物背景信息 | C57BL/6J |
| 模型制作方法 | 胚胎干细胞打靶 |
| 模型表型数据 | Tcrbtm1Mom和Tcrdtm1Mom靶向突变的纯合小鼠均不表达αβT细胞受体或任何γδT细胞受体。 |
| 动物模型的评价与验证 | 该模型小鼠，可用于研究炎症性肠病。 |
| 保存方式 | 冷冻 |
| 合作方式 | 仅限合作研究 |
| 相关文章 |
1. Hogquist KA; Jameson SC; Heath WR; Howard JL; Bevan MJ; Carbone FR. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. 2.Chen W; Jin W; Tian H; Sicurello P; Frank M; Orenstein JM; Wahl SM. 2001. Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med 194(4):439-53. 3.Dillon S; Agrawal A; Van Dyke T; Landreth G; McCauley L; Koh A; Maliszewski C; Akira S; Pulendran B. 2004. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol 172(8):4733-43. 4.Geissmann F; Jung S; Littman DR. 2003. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19(1):71-82. |
| 备注 |
京公网安备 11010502043083号