| 标识符 | CSTR:16397.09.0G01000331 |
|---|---|
| 资源中文名称 | Faslpr自发突变小鼠模型 |
| 资源英文名称 | MRL/MpJ- Fas |
| 疾病概述 | 免疫系统相关疾病 |
| 实验动物背景信息 | MRL/MpJ |
| 模型制作方法 | 自发突变品系 |
| 模型表型数据 | 自发突变（Faslpr）的小鼠表现出全身性自身免疫，与异常T细胞增殖相关的大规模淋巴结病，关节炎和免疫复合物肾小球肾病。 |
| 动物模型的评价与验证 | 该小鼠模型可用于研究淋巴结病，关节炎和自身免疫型疾病的研究。 |
| 保存方式 | 冷冻 |
| 合作方式 | 仅限合作研究 |
| 相关文章 |
1Andrews BS; Eisenberg RA; Theofilopoulos AN; Izui S; Wilson CB; McConahey PJ; Murphy ED; Roths JB; Dixon FJ.. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med，1978，148(5):1198-215. 2Clark LD; Clark RK; Heber-Katz E. A new murine model for mammalian wound repair and regeneration. Clin Immunol Immunopathol，1998，88(1):35-45. 3Drappa J; Brot N; Elkon KB. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr. Proc Natl Acad Sci U S A，1993，90(21):10340-4. 4Fields ML; Sokol CL; Eaton-Bassiri A; Seo Sj; Madaio MP; Erikson J. Fas/fas ligand deficiency results in altered localization of anti-double-stranded dna b cells and dendritic cells. J Immunol，2001，167(4):2370-8. 5Gu L; Weinreb A; Wang XP; Zack DJ; Qiao JH; Weisbart R; Lusis AJ. Genetic determinants of autoimmune disease and coronary vasculitis in the MRL-lpr/lpr mouse model of systemic lupus erythematosus. J Immunol，1998，161(12):6999-7006. 6Hewicker M; Kromschroder E; Trautwein G. Detection of circulating immune complexes in MRL mice with different forms of glomerulonephritis. Z Versuchstierkd，1990，33(4):149-56. 7Johnson BC; Morton JI; Trune DR. Lacrimal and salivary gland inflammation in the C3H/Ipr autoimmune strain mouse: a potential mode for Sjogren's syndrome. Otolaryngol Head Neck Surg，1992，106(4):394-9. 8Kawase E; Suemori H; Takahashi N; Okazaki K; Hashimoto K; Nakatsuji N. Strain difference in establishment of mouse embryonic stem (ES) cell lines. Int J Dev Biol，1994， 38(2):385-90. |
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