| 标识符 | CSTR:16397.09.0G01000333 |
|---|---|
| 资源中文名称 | CD47 antigen基因敲除小鼠模型 |
| 资源英文名称 | B6.129S7- Cd47tm1 |
| 疾病概述 | 免疫系统相关疾病 |
| 实验动物背景信息 | C57BL/6J |
| 模型制作方法 | 胚胎干细胞打靶 |
| 模型表型数据 | CD47基因敲除纯合小鼠是可存活的，可育的，并且没有明显的表型异常。 纯合突变小鼠显示出正常的血液计数，除了外周淋巴细胞的CD3 +分数降低外。 杂合小鼠中整联蛋白相关蛋白（IAP; CD47）的表达约为野生型的40％。 腹腔注射强力大肠杆菌会杀死该小鼠，表明宿主防御途径存在缺陷。 |
| 动物模型的评价与验证 | 此突变小鼠品系可能用于多形核白细胞（PMN）迁移到感染部位以及该部位激活缺陷的继发性反应的研究。 |
| 保存方式 | 冷冻 |
| 合作方式 | 仅限合作研究 |
| 相关文章 |
1Lindberg FP; Bullard DC; Caver TE; Gresham HD; Beaudet AL; Brown EJ. 1996. Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274(5288):795-8. 2Ball SL; Lindberg FP; Lagenaur CF; Peachey NS. 2001. Electroretinograms remain normal in mice lacking a synapse associated protein. Neurosci Lett 298(2):111-4. 3Beattie L; Svensson M; Bune A; Brown N; Maroof A; Zubairi S; Smith KR; Kaye PM. 2010. Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. Eur J Immunol 40(1):117-23. 4Bouguermouh S; Van VQ; Martel J; Gautier P; Rubio M; Sarfati M. 2008. CD47 expression on T cell is a self-control negative regulator of type 1 immune response. J Immunol 180(12):8073-82. 5Capo C; Lindberg FP; Meconi S; Zaffran Y; Tardei G; Brown EJ; Raoult D; Mege JL. 1999. Subversion of monocyte functions by coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3. J Immunol 163(11):6078-85. 6Chang HP; Lindberg FP; Wang HL; Huang AM; Lee EH. 1999. Impaired memory retention and decreased long-term potentiation in integrin-associated protein-deficient mice. Learn Mem 6(5):448-57. 7Fortin G; Raymond M; Van VQ; Rubio M; Gautier P; Sarfati M; Franchimont D. 2009. A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells. J Exp Med 206(9):1995-2011. |
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