| 标识符 | CSTR:16397.09.0L01000575 |
|---|---|
| 资源中文名称 | HBV全基因组转基因小鼠 |
| 资源英文名称 | B6.Tg(pT-HBV1.3)-GC/ILAS |
| 疾病概述 | 乙肝 |
| 实验动物背景信息 | C57BL/6J |
| 模型制作方法 |  |
| 模型表型数据 |  利用HBV全病毒建立的转基因小鼠2个品系（Tg1，Tg2）在肝脏组织有明显的HBV形成（箭头所示）。 |
| 动物模型的评价与验证 | 研究抗HBV药物和病毒扩增以及和宿主相互作用的模型。 |
| 保存方式 | 冷冻 |
| 合作方式 | 不限定 |
| 相关文章 |
1．Ganem D，Prince AM. Hepatitis B virus infection – natural history and clinical consequence. N Engl J Med 2004;350;1118-1129 2．EE, Matzke B. High-level hepatitis B virus replication in transgenic miceJ Virol. 1995 Oct;69(10):6158-69 3．Moriyama T, Guilhot S. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science. 1990 Apr 20;248(4953):361-4. 4．Kakimi K, Guidotti LG,Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med. 2000 Oct 2;192(7):921-30 5．Chisari FV, Pinkert CA A transgenic mouse model of the chronic hepatitis B surfa ceantigencarrier state. Science. 1985Dec6;230 (4730):1157-60. 6．Chisari FV, Filippi P.Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.Proc Natl Acad Sci U S A. 1987 Oct;84(19):6909-13 7．Tateno C, Yoshizane Y. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004 Sep;165(3):901-12. 8．Huang LR, Wu HL, An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection. Proc Natl Acad Sci U S A. 2006 Nov |
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