| 标识符 | CSTR:16397.09.0L01000574 |
|---|---|
| 资源中文名称 | Wip-1（PPM1D）基因剔除小鼠 |
| 资源英文名称 | B6.Wip-1(tm) |
| 疾病概述 | 癌症相关 |
| 实验动物背景信息 | C57BL/6J |
| 模型制作方法 | 干细胞打靶 |
| 模型表型数据 | PPM1D（WIP1），编码605氨基酸的蛋白质，具有两个和定为信号和3个PP2C serine/threonine 磷酸酯酶特征序列。PPM1D 是一个和蛋白。PPM1D（WIP1）基因剔除小鼠的外周血T细胞减少，和较小的胸腺，PPM1D调解P53活性。PPM1D具有抑制癌细胞生长的作用。 |
| 动物模型的评价与验证 | 该模型是肿瘤研究中重要模型。 |
| 保存方式 | 冷冻 |
| 合作方式 | 仅限合作研究 |
| 相关文章 |
1. Bernards, R. Wip-ing out cancer. Nature Genet. 36: 319-320, 2004. 2. Bulavin, D. V. Demidov, O. N. Saito, S. et al. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Nature Genet. 31: 210-215, 2002. 3. Bulavin, D. V. Phillips, C. Nannenga, B. et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nature Genet. 36: 343-350, 2004. 4. Choi, J. Nannenga, B. Demidov, O. N.et al. Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Molec. Cell. Biol. 22: 1094-1105, 2002. 5. Fiscella, M. Zhang, H. Fan, S. et al. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc. Nat. Acad. Sci. 94: |
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