| 标识符 | CSTR:16397.09.0G01000571 |
|---|---|
| 资源中文名称 | Rag2基因敲除小鼠 |
| 资源英文名称 | B6.Rag2(tm) |
| 疾病概述 | 免疫缺陷动物模型 |
| 实验动物背景信息 | C57BL/6J |
| 模型制作方法 | 敲除第三外显子 |
| 模型表型数据 | RAG2 敲除小鼠不产生成熟的 T 细胞或 B 细胞。 |
| 动物模型的评价与验证 | RAG2全称recombination activating gene 2,RAG2 敲除小鼠可能有助于造血和免疫系统缺陷、癌症、毒理学和异种移植/移植研究。 |
| 保存方式 | 冷冻 |
| 合作方式 | 仅限合作研究 |
| 相关文章 |
1. Adams, J. Kelso, R. Cooley, L. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell Biol. 10: 17-24, 2000. 2. Callebaut, I. Mornon, J.-P. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell. Molec. Life Sci. 54: 880-891, 1998. 3. Corneo, B. Moshous, D. Gungor, T. et al. Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B-severe combined immune deficiency or Omenn syndrome. Blood 97: 2772-2776, 2001. 4. Corneo, B. Wendland, R. L. Deriano, L. et al. Rag mutations reveal robust alternative end joining. Nature 449: 483-486, 2007. 5. Hikida, M. Mori, M. Takai, T. Tomochika, K. et al. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 274: 2091-2093, 1996. |
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